The San Francisco 49ers open their NFL regular season on the road at Soldier Field Sunday September 11 against the Chicago Bears. San Francisco will start the Trey Lance era at quarterback against Chicago. Deebo Samuel, who signed a three-year deal during preseason, is expected to be Lance’s favorite target downfield, while TE George Kittle will be his top overall receiver. Last year’s starting quarterback, Jimmy Garoppolo is still on the roster but the 49ers are entertaining trade offers.
San Francisco will pick up a victory on the road Sunday in their season opener against Chicago, but the play here is UNDER. The UNDER has cashed in 20 of Chicago's last 27 played at home as well as in 30 of the last 43 that the Bears have played on natural grass. The UNDER has also cashed in seven of San Francisco's last eight overall. San Francisco will have a new quarterback and the Chicago pass rush will pressure Trey Lance and forced turnovers and end possible drives. San Francisco 49ers at Chicago Bears Under the posted total.
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NFL Premium Pick For Sunday September 11, 2022 Game After 4pm.